UK research into CMN syndrome takes place at Great Ormond Street Hospital NHS Foundation Trust (GOSH) and the next-door UCL Institute of Child Health (ICH), and is led by Dr. Veronica Kinsler who works in both institutions. CMN have been described over many centuries, and are likely to have existed for as long as humans have been around. As with many other conditions, however, it is only recently that we have been able to start to understand what causes CMN and why it appears in particular people. In theory, with the right combination of patient participation in research studies, adequate funding, and good researchers most conditions in medicine will eventually be understood.
For the most up to date view of the research it is best to attend one of the family days, as Dr. Kinsler gives presentations into the latest findings. Publications in medical journals about the CMN research tend to come out in bursts, as many different projects are run in parallel. You will find links to the summaries of the publications that are already available below. If you would like to read the whole paper and this is not available online please email Dr. Kinsler (email@example.com) and a copy will be sent to you.
- Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling
- Classification of neurological abnormalities in children with congenital melanocytic naevus syndrome identifies MRI as the best predictor of clinical outcome
- Next-Generation Sequencing of Nevus Spilus-Type Congenital Melanocytic Nevus: Exquisite Genotype-Phenotype Correlation in Mosaic RASopathies
- Immunohistochemical and ultrastructural features of congenital melanocytic naevus cells support a stem cell phenotype
- Multiple Congenital Melanocytic Naevi and Neurocutaneous Melanosis are Caused by Post-Zygotic Mutations in Codon 61 of NRAS
- Germline Melanocortin-1-Receptor Genotype Is Associated with Severity of Cutaneous Phenotype in Congenital Melanocytic Nevi: A Role for MC1R in Human Fetal Development
- The face in congenital melanocytic nevus syndrome
- Neuropathology of neurocutaneous melanosis: histological foci of melanotic neurons and glia may be undetectable on MRI
- Satellite lesions in congenital melanocytic nevi – time for a change of name
- The role of surgery in the management of congenital melanocytic naevi in children: a perspective from Great Ormond Street Hospital
- Great Ormond Street Hospital for Children Registry for Congenital Melanocytic Naevi: prospective study 1988-2007. Part 2- Evaluation of treatments
- Great Ormond Street Hospital for Children Registry for Congenital Melanocytic Naevi: prospective study 1988-2007. Part 1 – epidemiology, phenotype and outcomes
- Complications of congenital melanocytic naevi in children: analysis of 16 years’ experience and clinical practice